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Neurocysticercosis is an infection that affects the central nervous system and occurs due to the larvae of Taenia solium. It is
the most common helminthic infection and the most usual cause of acquired epilepsy in developing countries like India. The
diagnostic criteria vary from being asymptomatic to life-threatening symptoms like throbbing headache, seizures, nausea,
visual disturbances, diarrhea, abdominal cramps. The main cause behind NCC is accidentally ingesting eggs of tapeworm
Taenia solium via contaminated food like partially cooked pork, beef, and uncooked and not thoroughly washed vegetables.
In order to confirm the presence of lesion different diagnostic tests like Computed tomography scan, Magnetic resonance
imaging of brain and serology are preferred. This study is to spotlight the case of a 23-year-old young boy who came to the
medicine department with chief complaints of severe headache, dizziness, blurred vision, a lapse of memory and seizures
from the past 15 days. The MRI Brain Spectroscopy with contrast indicated a cystic lesion in the left medial temporal lobe
with an inflammatory granuloma-likely degenerative neurocysticercosis cyst.

over the lower front of the neck and they produces several hormones that helps in proper working of our body. High level thyroid hormone in the body is referred as thyrotoxicosis, it also means a condition where there is a low level of thyroid stimulating hormone TSH in blood stream. Thyrotoxicosis is often called as hyperthyroidism but both of them slightly differ in their definition. Hyperthyroidism is a condition where thyroid gland produces too much of thyroxin hormone which is also one of the cause of thyrotoxicosis. A 57 year old female patient weighing 45 kg from semirural area was admitted to MVJ Medical College & Research Hospital with complaints of swelling of neck from 6 months without any pain and no difficulty in swallowing which was gradual in onset but progressed later. The patient also had the complaint of palpitation and cough with expectoration. Patient was diagnosed with hypothyroidism causing Thyrotoxicosis, and appropriate treatment was given to the patient and condition was improved at the time of discharge. From this case study it can be concluded that the combination therapy of appropriate medications and lifestyle modifications can provide promising results in improving Hyperthyroidism and thus can stop further complication of Thyrotoxicosis.Key Words:- Thyroid gland, Thyrotoxicosis, Thyroid hormone, Hyperthyroidism.

Early findings from biologic research suggest that the administration of NSAIDS may reduce the risk of cancer. Evidence has come from animal toxicology, experimental pharmacology, clinical medicine, and epidemiology. Preclinical and clinical studies have clearly shown a benefit of non-steroidal anti-inflammatory drug (NSAID) use in reducing cancer risk. NSAIDs are a chemically diverse family of drugs available over-the-counter or by prescription and are commonly used for the treatment of inflammation, pain, or fever. Many drugs belong to the class of drugs known as the NSAIDs. Some examples of NSAIDs include ibuprofen, mefenamic acid, celecoxib, aspirin, and diclofenac drugs have one common property, i.e., their ability to block the enzyme cyclooxygenase (COX). COX are enzymes that are involved in the synthesis of prostaglandins (PGs), which are derived from the arachidonic acid pathway. It is also found that some distinguish characteristics of NSAIDS are induced tumor cell apoptosis, down regulation of EGFR expression, protect and repair DNA damage, etc.

Major depression is a chronic illness with a high prevalence rates in the society. Depression affects an estimated
6.7% of today’s adult population. Depression is found to be fatal condition if not diagnosed at right time and treated
accurately. Several risk factors and conditions can aggravate symptoms of depression or increase the risk to develop
depression. There are many studies carried out throughout the world with a common agenda to identify the underlying risk
factors and establish correlation with the present disease condition and depression. There are several established relations
that may have a link with the possible disease and depression developing risk factors.

Flaccid paraplegia is mainly paralysis of two corresponding extremities, and is the antithesis of spastic paraplegia.
It may result from different causes. Transverse myelitis is an inflammation of both sides of one section of the spinal cord.
This neurological disorder often damages the insulating material covering nerve cell fibers (myelin). The exact reason for
transverse myelitis is not known. Sometimes there is no known cause. A female patient was admitted to tertiary care
hospital with complaints of weakness of lower leg, immobility of legs, unable to sit or stand, pain over spine. Bladder
incontinence, decreased appetite associated with cold and cough and was diagnosed with flaccid paraplegia with transverse
myelitis and this patient was cured with proper treatment which avoided further complications.

Red cell distribution (RDW) width has been established as being affected in patients with diabetes, especially with poor glycemic control. Further, studies have shown that there is a certain degree of anemia, even in young males with type 2 diabetes, as associated to healthy volunteers. High RDW designates impairment of erythropoiesis, reflecting chronic inflammation and increased levels of oxidative stress. In this study, the mean HB was 12.81 mg/dl with 95% CI of 12.56 -13.07, which reflects mild anemia. A mean Hb of 11.17±4.42 g/dl in diabetics as compared to 14.11 g/dl in the non-diabetic Indian population. The mean MCV in this study population was 84.52 fl while the mean MCH was 27.59 pg, which are within normal limits, indicating that the anemia observed is probably a normocytic normochromic anemia due to chronic disease. In the present study, the mean RDW was 13.76 (95% CI 13.45-13.95) in the study population. This study also observed that Red cell distribution width (RDW) was meaningfully higher in diabetic patients than in control subjects

The aim of this research is to create microemulsion formulations to increase the bioavailability of Itraconazole that are poor in bioavailability. Itraconazole microemulsion (10 formulations) is prepared and optimised by phase titration technique and screened Itraconazole microemulsion is selected for in vivo pharmacokinetic performance assessment in albino wistar rats from this optimization study results. Invivo pharmacokinetic tests showed positive findings in the formulation of IM9. This research shows an improvement in Cmax in Itraconazole microemulsion, which shows greater bioavailability than the branded Itraconazole capsule (Sporanox ® Capsule). This research shows an increase in AUC0- ∞; Tmax; Microemulsion has been concluded to be a promising method for improving the bioavailability of drugs such as Itraconazole