ABSTRACT
in Hypertension, Colon targeting drug delivery system plays a vital role in releasing the drug at early morning hours by delaying the release of drug from dosage form by applying novel approaches in it. This approach happens due to the chronological behavior of Hypertension confirms increased blood pressure at early morning hours, this need a preferable dosage form which will provide desired concentration of the drug at pre-determined time points especially early in the morning. The prepared dosage forms were optimized and evaluated. About eight formulations of Metoprolol tartarate microbeads were formulated with the help of different polymers, cross linking agent and coating polymer solution. From the invitro release studies datas it shows that MF2 was found to be an ideal formulation for colon targeting. It shows maximum amount of cumulative drug release from MF2 formulation, which was found to be 98.25±0.5 % at 16th hr in Colonic pH after lag time. From these studies it confirms that the delayed time and drug release profile of Metoprolol tartarate release from microbeads leads to sustainability and targetability of drug in colon.
Key Words:- Colon targeting, Metoprolol tartarate, Hypertension, Metoprolol tartarate.
