1. | CASUAL RELATIONSHIP BETWEEN PROGRESSION OF CANCER
AND PRESCRIBED NSAIDS-COMPREHENSIVE REVIEW |
| Gnana prasuna G*, Madhu Latha G, Chaitanya U, Pallavi P, Baba Khadhar Vali Sk |
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This comprehensive exploration delves into the multifaceted relationship between Nonsteroidal Anti-Inflammatory Drugs
(NSAIDs) and cancer, with a specific focus on colorectal cancer. The synthesis of extensive clinical data establishes
NSAIDs as pivotal in cancer treatment, particularly in colorectal cancer prevention. The National Comprehensive Cancer
Network's recognition of NSAIDs in the 2017 colorectal cancer guide signifies a milestone in integrating these drugs into
clinical protocols. While long-term NSAID use exhibits anticancer effects, the associated side effects necessitate a nuanced
consideration of risks and benefits for individual patients contemplating cancer chemoprophylaxis. The review encompasses
the mechanisms underlying NSAID action, their impact on inflammatory pathways, angiogenesis, immune modulation, and
their role in preventing cancer metastasis. The nuanced discussion highlights the need for future research, emphasizing
molecular classifications, population-specific studies, and optimal NSAID dosage for maximizing anticancer benefits.
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2. | NON-SMALL CELL LUNG CANCER (NSCLC)-DIAGNOSTIC AND
THERAPEUTIC OPTIONS |
| Gnana Prasuna G*, Anupama P, Venkatesh M, Prasanna Kumar Naik B |
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The lungs play a crucial role in sustaining life by collaborating with the heart and circulatory system to supply essential
oxygen to the body. They possess a remarkable reserve capacity, working efficiently even under various conditions.
Similarly, the heart and circulatory system have a reserve capacity, enabling cancerous lung tumours to grow over several
years without hindering lung function. Additionally, the lungs have fewer nerves for pain transmission, allowing cancer to
progress for an extended period without causing noticeable symptoms. Despite being a global health concern, lung cancer is
often asymptomatic in its early stages, making it a challenging disease to detect. The prognosis for lung cancer, particularly
non-small cell lung cancer (NSCLC), is generally more favourable when diagnosed early. NSCLC is considered a lifethreatening condition, and early detection coupled with prompt intervention is crucial. Treatment options such as surgery,
radiation therapy, and chemotherapy can significantly contribute to a positive prognosis for individuals with non-small cell
lung cancer. Early diagnosis and swift initiation of appropriate therapies are paramount in improving outcomes and
increasing the chances of successful treatment
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3. | FORMULATION AND IN-VITRO EVALUATION OF
HALOPERIDOL PATCHES FOR TRANSDERMAL DRUG
DELIVERY SYSTEM |
| Shaik Fareed Malik1*, Dr. Purushothaman M |
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Haloperidol is a high potency first-generation (typical) antipsychotic and one of the most frequently used antipsychotic
medications used worldwide. While haloperidol has demonstrated pharmacologic activity at a number of receptors in the
brain, it exerts its antipsychotic effect through its strong antagonism of the dopamine receptor (mainly D2), particularly
within the mesolimbic and mesocortical systems of the brain. Haloperidol is indicated for the treatment of the manifestations
of several psychotic disorders including schizophrenia, acute psychosis, Tourette syndrome, and other severe behavioural
states. In present study transdermal drug delivery of Haloperidol was developed to overcome the first pass metabolism and
to reduce frequency of dosing compared to oral route. Matrix type of transdermal patches was developed by using polymers
various Xanthan gum, MethocelK15M and MethocelK100M as polymers Transdermal patches were prepared by employing
solvent casting method. Drug excipient compatibility studies were carried out by using FTIR, and it was observed that there
were no interactions. Formulations were prepared with the varying concentrations polymers ranging from F1-F9, and all the
formulations were evaluated for various physical parameters Physical appearance, Flatness, Weight variation, Thickness,
Folding endurance, Drug content, Moisture uptake, Moisture content and all the results were found to be were found to be
with in the pharmacopeial limits, invitro drug release studies by using dialysis membrane. Among all the 9 formulations F7
formulation which containMethocel K100M 100 mg had shown 97.83% cumulative drug release within 12 hours
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