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A study was conducted in Santhiram medical college and general hospital, Nandyal from July 2017 to December
2017, to evaluate the knowledge and prevalence of diabetic complications in diabetic patients of a tertiary care teaching
hospital. Patient data was collected by using questionnaire which was prepared by ourselves and was thoroughly evaluated
by physicians and healthcare professionals. About 97 diabetic patients were evaluated for the knowledge and prevalence of
diabetes and its complications out of which 41 patients have answered correctly to our questionnaire. The mean age of the
patients was 54.7 years. Most knowledgeable group was 51-60 years. Out of 41 knowledgeable patients, Males (29) were
more knowledgeable regarding complications of diabetes than females(12). In Frequency distribution of the most serious
complication of diabetes mellitus, Diabetic foot (34) was found to be major complication when compared to
Nephropathy(20), Retinopathy (17) and others include Neuropathy, CVD, Stroke (16). The overall knowledge about
diabetes among the diabetic patients was only 42.4% which shows that the knowledge regarding diabetes was less in our
study population. Hence, it is necessary to educate the patients regarding diabetes and its complications by conducting
Diabetic health care programmes and providing patient counseling by health care professionals in a local language so that
they could understand and lead their life in a healthy way.

Allium sativum Linn is a popular Indian herb which is used as Antimicrobial, Anticancer, Antioxidant, Antiadrogenic,
Hepatoprotective, Anticoagulant, Hypocholestermic, Antiarthritic, Antihypertensive etc. The aim of present study was to
evaluate anticonvulsant activity of EEAS (Ethanolic Exctract of Allium sativum Linn) against MES and Isoniazid
(INH300mg/kg i.p) induced convulsions in wistar rat. All the animals were divided into five groups of six rat each (n=6)
induced by MES and INH (300mg/kg intraperitonially) convulsions respectively. In method I Group I treated as control, Group
II was induced by MES. Group III was treated with Phenytoin(25mg/kg b.w.p.o) and MES Group IV was treated with EEAS
(200 mg/kg p.o.) and MES. Group V was treated with EEAS (400mg/kg p.o.) and MES. In Method II Group I was treated as
control, Group II was induced with INH 300mg/kg i.p.\Group III was treated with Phenytoin(25mg/kg b.w.p.o) and INH
(300mg/kg intraperitonially), Group IV was treated with EEAS (200 mg/kg p.o.) and INH (300mg/kg intraperitonially), Group
V was treated with EEAS (400 mg/kg p.o.) and INH (300mg/kg intraperitonially) respectively. The result showed that EEAS
significantly reduced duration of clonic convulsions in MES and also delayed the onset of convulsions induced by INH. EEAS
showed anticonvulsant activity in MES and INH induced convulsions in animals. Brain homogenate of GABA, Histopathology
and Antioxidant SOD, LPO, GPx, Catalase were estimated.