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ABSTRACT Albizia lebbeck is commonly known as Shirish, has various therapeutic properties. Use of Albizia lebbeck has been comprehensively recommended to remove toxins from the human body. It also use for the treatment of respiratory tract problem like asthma, allergies, anti-tussive and seasonal cold. Researches on Albizia lebbeck also reported anti-inflammatory, anti-asthematic, anti-microbial and anaphylatic, analgesic, anti-diarrhoeal, immunomodulatory properties of the plant. It is considered as an antidote against all types of poisions. The plant contains saponin, alkaloids, glycosides and flavonoids. Albizia lebbeck potential in some antioxidants such as DPPH free radical scavenging activity, nitric oxide scavenging activity, hydrogen peroxide scavenging activity and reducing power assay. Albizia lebbeck has taken as an important medicinal tree found in India arid zone resion. Key Words:- Albizia lebbeck, Anti-tussive, DPPH, Saponin, Antidote, Immunomodulatory.

ABSTRACT Nutraceutical is the hybrid of „nutrition‟ and „pharmaceutical‟. Nutraceuticals; in broad, are food or part of food playing a significant role in modifying and maintaining normal physiological function that maintains healthy human beings. The food products used as nutraceuticals can be categorized as dietary fibre, prebiotics, probiotics, polyunsaturated fatty acids, antioxidants and other different types of herbal natural foods. These nutraceuticals used in various diseases such as obesity, cardiovascular diseases, cancer, osteoporosis, arthritis, diabetes, cholesterol etc. In whole, „nutraceutical‟ has lead to the new era of medicine and health, in which the food industry has become a research oriented sector. This article aim to provide the knowledge of nutraceutical with its uses in various diseases. Key Words:- Dietary Fiber, Prebiotics, Probiotics, Polyunsaturated Fatty Acids, Antioxidants.

ABSTRACT This study was carried out to investigate the influences of oral administration of aqueous extract of Matricaria chamomile and curcumin in nephrotoxicity induced in rats by Tetracyclinees for 4 weeks. The effects were determined via estimation of kidney functions and hitopathological changes. Rats were divided into six groups (6 rats each). The first group (G1) were healthy animals treated by Distal Water (DW, IP). In groups 2-6, nephrotoxicity was induced by Tetracycline (25 mg/ kg BW IP), Group 2 treated by DW, groups 3 and 5 rats treated with either Matricaria chamomile extract or curcumin (50 mg/kg BW and 200mg/kg BW respectively) without disease induction, while the animals in groups 4 and 6 were received a combination of full dose of Matricaria chamomile or curcumin with Tetracyclinee for 14 days. Tetracycline nephrotoxicity associated with significant increase in the serum urea, createnine Na+ and K+ with significant (P<0.01) decline in serum protein.However, co-administrated of Matricaria chamomile and curcumin extracts with Tetracycline appeared to be ameliorate te adverse effects of Tetracyclinee in renal function tests. On the other hand, histopathological examination of kidney sections of Tetracyclinee induction neprotoxic non treated showed marked attenuated the severity of Tetracycline nephrotoxicity, However, all these toxic effects were improved by administration of Matricaria Chamomisleor curcumin extract, but didn’t bring them to the control limits. According to results the co-administration of Matricaria chamomile or curcumin with Tetracycline had beneficial effects on Tetracyclinee nephrotoxicity. Key Words:- Nephroprotective, Matricaria chamomile, Curcumin, Albino rats, Histopathology.

ABSTRACT Aristolochia bracteolate is a small glabrous shrub occurring in india. It belongs to the family Aristolochiaceae. The whole plant is used in various ailments like abortifacient, alterative, anthelmintic, antiperiodic, emmenagogue and purgative. The stem and root having the aristolochia acid (Alkaloid). The leaves and roots are used to rid the body of Guinea worm (a parasitic infection caused by a nematode).In present study was macroscopical, microscopy, physiochemical parameters (extractive values, crude fibre content , ash values, foreign organic matter) , fluorescent analysis, plant cell inclusions reported. The ethanolic plant extraction was carried out by using soxhlet apparatus. The extract was screened for phytochemical properties by using colour reaction test. Key Words:- Aristolochia bracteolate, Antiperiodic, Macroscopical, Microscopy, Soxhlet.

ABSTRACT The present study confirms the safety of stem bark of Neisosperma oppositifolium (Lam.) Fosb. & Sachet by subjected to acute and chronic toxicological studies. Acute oral toxicity study was performed as per OECD 423 guidelines, albino Wistar rats of either sex selected by random sampling technique were used for acute toxicity study. Test group animals received test extracts (500mg/kg, oral) once daily for 90days. Toxicological indications and symptoms were recorded daily. All groups of animal feed consumption, and animal’s weight were monitored at the end of the day 0, day 30, day 60 & day 90. Similarly, hematological and biochemical parameters were estimated on day 0, day 30, day 60 & day 90. In conclusion, at the oral dose 500mg/kg, of Ethyl acetate extract of stem bark of Neisosperma oppositifolium (Lam.) Fosb. & Sachet (EAENo), Ethanol extract of stem bark of Neisosperma oppositifolium (Lam.) Fosb. & Sachet (EAENo), can be considered as safe and these extracts did not cause any lethality and adverse effects or changes in general behaviour, haematological and biochemical parameters in the chronic toxicity study in rats. Key Words:- Neisosperma oppositifolium, Acute toxicity, Chronic toxicity.

ABSTRACT Nasal route has been a preferred choice of administrating certain types of drugs. It has been explored as an alternative route for administration of vaccines and biomolecules such as proteins, peptides and non-peptide drugs, hence it has attracted the interest of scientific community. Nasal route is beneficial for the drugs which are unstable on oral administration because they are significantly degraded in GIT or metabolized by first pass effect in liver. Nasal route is alternative to parenteral therapy and also useful for long term therapy. Nasal mucosa is highly vascularized and most permeable giving rapid absorption and onset of action. Nasal route is noninvasive, widely used for the local treatment may also be used for systemic therapy as drug directly goes in systemic circulation. Nasal route gives good absorption of small molecules, then that of large molecules can be increased by absorption promoters. Thus, Intranasal therapy holds a great promise of research to understand the potentiality and limitation of it and possible use of this route for delivering different drugs. The aim of this review is to discuss the prospect of nasal spray as an innovative drug delivery system for local or systemic drug administration. It is expected that this review will help to understand and further to develop suitable intra- nasal formulations to achieve specific therapeutic objectives. Key Words:- Nasal route, pharmacokinetic parameters, nasal absorption enhancers, Factors , Excipients ,Formulation, Evaluation, Models.

Scabies is a not unusual communicable disorder of the skin due to a mite.It is a mistreated tropical parasitic disease that is a
essential public fitness trouble international and in particular in resource-poor areas. As WHO document, 2018 indicated
scabies is a routine public health problem that affects about 200 million people globally, with a predictable prevalence that
range from 0.2 to 71%. To study the Prevalence and characterization of dermatology disorder of Scabies at a rural Tertiary
Care Centre This is a cross-sectional online study conducted in the period of 6 months from March to August 2021,
diagnosed patients attending skin OPD with clinical features suggestive of scabies. Out of 120 patients, 63.3% were males.
The most common age group affected was 21-40 years, in 40% patients. Maximum 53.6% adults had small effect on quality
of life while 69.5% children reported minimal effect on quality of life. Even though the best knowledge of scabies, the level
of fear towards scabies is high. if not attended timely and adequately can affect the quality of life in the form of work
affection, sleep disturbances and psychosocial problems in patients and its family members. Further educational programs
suggested decreasing the negative effect of scabies on the community and the individuals’ quality of life

Total knee replacement (TKR) has a diagnosed region inside the remedy of knee osteoarthritis and is considered to be an
effective intervention. To look into sufferers’ studies of outcome from a complete knee replacement (TKR).In-intensity
interviews were conducted with 50 sufferers three months before TKR, with 30 interviewed once more 6 months after surgical
procedure. Patients had been purposively sampled to consist of a variety of demographic traits. Interviews were audio taped
and transcribed. Methods of consistent evaluation were used to examine the records. Individuals struggled to make sense in
their final results and often defined it in contradictory terms. When requested without delay, maximum reported a great final
results, but similarly dialogue revealed challenge and discomfort with continuing pain and mobility problems. These
apparently contradictory debts have been consistent with the presentation of public and personal perspectives, have been
dependent on the context of patients’ lives, and represented a model to their changed fitness state. Individuals stated their
outcome from TKR as right regardless of the ongoing experience of ache and immobility.