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ABSTRACT Increasing urbanization and industrialization is causing stress to the water resources because of unlimited obstruction of water and discharge of industrial and municipal wastes into the same water bodies like river. Domestic or Industrial waste if discharged into River water can give rise to significant deterioration in its quality. Four different locations near Kanha River were selected for the study and compared. The parameters studied were pH, total alkalinity, total hardness, turbidity, chloride, sulphate, fluoride, total dissolved solids and conductivity. From overall analysis, it was observed that there was a slight fluctuation in the physico-chemical parameters among the water samples studied. Comparison of the physico-chemical parameters of the water sample with WHO and ICMR limits showed that the river water is slightly contaminated and account for health hazards for human use. Key Words:- Industrialization, Deterioration, Municipal wastes, Parameters, Health hazards.

ABSTRACT Pediculosis is a world-wild extended ectoparasitosis with great impact on school children. There are different compounds used therapeutically against this parasitosis, but most of them have been designed to combat pests in the form of insecticides being in many cases very dangerous. The fish are used as models to determine the acute toxicity through the measuring the mortality of various species. In this work we evaluated the acute toxicity of ten formulations of pediculicides formulated with different actives principles by using fish (Poecilia reticulate). The results showed that pediculicides formulated with natural products are less toxic compared with those formulated with synthetic products. The toxicity varies and depends mainly on the type and concentration of active ingredient. Our results indicate that it is not justified to use pediculicides formulated with lindane because it is significantly more toxic than any of the pediculicides available. Key Words:- Pediculicides, Acute toxicity, Fish.

ABSTRACT Itraconazole is one of the important orally and topically triazole antifungal drugs which is extreme example of class II biopharmaceutical classification system and has side effects such as nausea, vomiting, hypokalemia, rash and other side effects when its taken orally. The drug was prepared as emulgel which has emerged as one of the most interesting way to deliver hydrophobic drug topically as it has dual release control system i.e., emulsion and gel. The prepared formulations were evaluated on basis of pH, spreadability, drug content, and In vitro release, In vitro antifungal activity, Skin irritation studies on rat and rheological behavior was also performed to the selected formula which gave the maximum release (95.3%) in 6 hours. The result of In vitro antifungal compared with marketed clotrimazole cream (1%), shows a wider zone of inhibition for the itraconazole emulgel as compared with marketed cream. While the result of irritation test showed no edema and erythema and demonstrated shear thinning thixotropic behavior. Hence it can be concluded that emulgel based system is more effective and safe system for delivery of antifungal agents. Key Words: - Itraconazole, Emulgel, Carbopol 971P NF, Topical drug delivery.

Enormous amount of shell wastes are generated due to industrial processing of crabs and prawns. Natural means of shell degradation becomes slower due to large quantities of shell waste dumped in the lands or burning them cause major environmental issues. So it is essential and necessary to reduce, recycle and reuse these shell waste. The present study was conducted using the crab shell powder of two different sizes (0.2 mm and 0.4 mm) to verify the minerals, protein, lipid, chitin, chitosan, moisture and carotenoid content of male and female freshwater crab, Oziotelphusa senex senex by traditional chemical method slightly modified. The minerals and lipids was recorded to be high in female crab shell waste than that of male crab shell waste, whereas the proteins, chitin and chitosan was recorded to be highest in male crab shell waste than that of female crab shell waste of both the particle size. The moisture and carotenoid content was almost same for of all particle size of male and female crab shell powder. The statistical analysis (t-test) showed a significant difference between male and female crab shell waste. Some bioactive compounds present in this crude shell waste of a fresh water crab, Oziotelphusa senex senex had an antioxidant activity. The results of the present study confirmed that the crude male shell waste had highest antioxidant activity. Key Words:- Chitin, Chitosan, Qualitative, Quantitative, Carotenoid, Antioxidant, Oziotelphusa senex senex.

ABSTRACT Evaluated the antibacterial effect of aqueous and ethanolic extract of the leaf, bark of Murraya koenigii L. against previously characterized Staphylococcus aureus and Streptococcus pyogenes was analyzed in this study. Aqueous and ethanolic extract of the leaf, bark of Murraya koenigii L. were prepared with help of soxhlet unit. Further, evaluated the antimicrobial activity of these extract were analyzed against S. aureus and S. pyogenes. Aqueous and ethanolic extract of the leaf and bark of Murraya koenigii showed significant antibacterial activity against Staphylococcus aureus and Streptococcus pyogens. 15 μg/ml extract of leave showed 47.05% more inhibition zone against Staphylococcus aureus as compared to 15μg/ml norflox (control drug) and 15, 20, 25, 30, 35 μg/ml extract showed 13.55, 27.11, 41.01, 47.47, 61.01% more antimicrobial activity against Streptococcus pyogens as compared to 15μg/ml norflox (control drug). Aqueous extract of bark Murraya koenigii showed significant antibacterial activity. 15 μg/ml extract showed 229.41% more inhibition zone against Staphylococcus aureus as compared to 15μg/ml norflox (control drug). Key Words:- MIC, MBC, Murraya koenigii, Staphylococcus aureus, Streptococcus pyogenes.

ABSTRACT This research focuses on the phytochemical study of ethanolic extract (70%), aqueous extracts (cold, hot) and juice of Actinidia deliciosa. The checking of phytochemical constituents involved the qualitative and quantitative analysis. The results for qualitative tests explained that the ethanolic extract and juice contains more amounts of active components such as flavonoids, alkaloids, terpenoids, glycosides and amino acids or primary and secondary amines rather than cold extract and hot extract, also the quantitative analysis illustrated that the ethanolic extracts and juice contains more amounts of flavonoids, and alkaloids because the ethanolic extracts and juice still have high yield from all active components and this result may be due to the type of solvent in the ethanolic extract and fruit juice are nutritious contain more active compounds and due to the increased healthy life style becoming more popular drinks. The Thiobarbituric Acid (TBA) reactive substances assay is a simple and quick assay for the assessment in plants of lipid peroxidation, in which Malondialdehyde (MDA) was evaluated. The ethonolic extract show high level of MDA than aqueous extracts and juice. Another type of antioxidant measured was vitamin E, a protective agent against oxidative stress. Total phenolic content was estimated by employing folin -Ciocalteu reagent and the results show the ethanolic extract contain large amount of total phenolic than other extracts. Also study the antioxidant activity by using DPPH (2,2-diphenyl-1-picrylhydrazyl) as stable free radical and the result illustrated the ethanolic extract have large percent of inhibition DPPH compared with other extracts and juice. Key Words:- Actinidia deliciosa, Phytochemical constituents, Vitamin E, Malondialdehyde, Total phenolic compounds, Alkaloids, DPPH, Egg yolk.

ABSTRACT Nanoparticles have a promising action in a variety of areas and fields. Plant based nanoparticle synthesis become advantageous than chemical synthesis. The present study involves green approach for the synthesis of silver nanoparticles (AgNPs) using Acranythes aspera as the source of phytochemicals for reducing and capping agent for the reduction of silver ions to silver atoms and stabilization of the particles. The nanoparticles were synthesized and characterized by using UV-Vis spectroscopy, Scanning Electron Microscopy (SEM) and FTIR analysis. Based on the findings, silver nanoparticle synthesizing A.aspera seed has the ability and capacity to act as an anti-inflammatory activity against carrageenan induced albino rats. Key Words:- Acranythes aspera, Silver Nano, UV, FTIR, SEM, Anti-inflammatory activity.